Bioaccumulation as a mechanism of microbiome/drug interactions. Issue 2 (February 2022)

• Record Type: Journal Article
• Authors: Cohen, Ziv; Kelly, Libusha
• Is Part Of: Trends in microbiology. Volume 30:Issue 2(2022)
• Page Start: 99
• Page End: 101
• Publication Date: 2022-02
• Subjects: Microbiology -- Periodicals; Infection -- Periodicals; Virulence (Microbiology) -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Virulence -- Periodicals; Microbiologie -- Périodiques; Infection -- Périodiques; Virulence (Microbiologie) -- Périodiques; Infection; Microbiology; Virulence (Microbiology); 579
• DOI: 10.1016/j.tim.2021.12.003
• Languages: English
• ISSNs: 0966-842X

Abstract

Abstract : Microbes of the human gut can change drug disposition in the human body and gut ecology via 'bioaccumulation', a process in which bacteria take up compounds intracellularly without chemically modifying them or experiencing changes in growth, as described in Klünemann et al . This work expands current understanding of the types of drug–bacterial interactions in the gut environment.