Changes in paediatric respiratory infections at a UK teaching hospital 2016–2021; impact of the SARS-CoV-2 pandemic. Issue 1 (January 2022)

• Record Type: Journal Article
• Authors: Lumley, Sheila F.; Richens, Nicholas; Lees, Emily; Cregan, Jack; Kalimeris, Elizabeth; Oakley, Sarah; Morgan, Marcus; Segal, Shelley; Dawson, Moya; Walker, A. Sarah; Eyre, David W.; Crook, Derrick W.; Beer, Sally; Novak, Alex; Stoesser, Nicole E.; Matthews, Philippa C.
• Is Part Of: Journal of infection. Volume 84:Issue 1(2022)
• Page Start: 40
• Page End: 47
• Publication Date: 2022-01
• Subjects: Respiratory virus -- Respiratory tract infection -- Paediatric -- SARS-CoV-2 -- Respiratory syncytial virus -- Influenza -- Rhinovirus; Infection -- Periodicals; Bacterial Infections -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.905
• DOI: 10.1016/j.jinf.2021.10.022
• Languages: English
• ISSNs: 0163-4453

Abstract

Highlights: Paediatric respiratory virus seasonality in Oxfordshire was altered by the SARS-CoV-2 pandemic. Detection of all pathogens was suppressed during the first national lockdown. SARS-CoV-2 incidence reflects the national pandemic infection curves. Rhinovirus and adenovirus rates increased when schools reopened Sept-Dec 2020. An inter-seasonal rise in RSV was seen in July 2021, influenza remained supressed. Abstract: Objective To describe the impact of the SARS-CoV-2 pandemic on the incidence of paediatric viral respiratory tract infection in Oxfordshire, UK. Methods Data on paediatric Emergency Department (ED) attendances (0–15 years inclusive), respiratory virus testing, vital signs and mortality at Oxford University Hospitals were summarised using descriptive statistics. Results Between 1-March-2016 and 30-July-2021, 155, 056 ED attendances occurred and 7, 195 respiratory virus PCRs were performed. Detection of all pathogens was suppressed during the first national lockdown. Rhinovirus and adenovirus rates increased when schools reopened September-December 2020, then fell, before rising in March-May 2021. The usual winter RSV peak did not occur in 2020/21, with an inter-seasonal rise (32/1, 000 attendances in 0–3 yr olds) in July 2021. Influenza remained suppressed throughout. A higher paediatric early warning score (PEWS) was seen for attendees with adenovirus during the pandemic compared to pre-pandemic ( p = 0.04, Mann-Witney U test), no other differences in PEWS were seen. Conclusions SARS-CoV-2 caused major changes in the incidence of paediatric respiratory viral infection in Oxfordshire, with implications for clinical service demand, testing strategies, timing of palivizumab RSV prophylaxis, and highlighting the need to understand which public health interventions are most effective for preventing respiratory virus infections.