Health‐related quality of life around the time of diagnosis in patients with bladder cancer. (7th June 2019)

• Record Type: Journal Article
• Authors: Yu, Evan Yi‐Wen; Nekeman, Duncan; Billingham, Lucinda J.; James, Nicholas D.; Cheng, KK; Bryan, Richard T.; Wesselius, Anke; Zeegers, Maurice P.
• Is Part Of: BJU international. Volume 124:Number 6(2019)
• Page Start: 984
• Page End: 991
• Publication Date: 2019-06-07
• Subjects: quality of life -- time of diagnosis -- cohort study -- QLQ‐C30 questionnaire -- #BladderCancer -- #blcsm; Genitourinary organs -- Diseases -- Periodicals; Genitourinary organs -- Surgery -- Periodicals; Urology -- Periodicals; 616.6
• DOI: 10.1111/bju.14804
• Languages: English
• ISSNs: 1464-4096

Abstract

Abstract : Objectives: To quantify the health‐related quality of life (HRQoL) of patients with bladder cancer around the time of diagnosis and to test the hypotheses of a two‐factor model for the HRQoL questionnaire QLQ‐C30. Methods: From participants in the Bladder Cancer Prognoses Programme, a multicentre cohort study, sociodemographic data were collected using semi‐structured face‐to‐face interviews. Answers to the QLQ‐C30 were transformed into a scale from 0 to 100. HRQoL data were analysed in multivariate analyses. The hypothesized two‐factor (Physical and Mental Health) domain structure of the QLQ‐C30 was also tested with confirmatory factor analyses (CFA). Results: A total of 1160 participants (78%) completed the questionnaire after initial visual diagnosis and before pathological confirmation. Despite non‐muscle‐invasive bladder cancer (NMIBC) being associated with a higher HRQoL than carcinoma invading bladder muscle, only the domain Role Functioning was clinically significantly better in patients with NMIBC. Age, gender, bladder cancer stage and comorbidity all had a significant influence on QLQ‐C30 scores. The CFA showed an overall good fit of the hypothesized two‐factor model. Conclusion: This study identified a baseline reference value for HRQoL for patients with bladder cancer, which allows better evaluation of any changes in HRQoL as disease progresses or after treatment. In addition, a two‐factor (Physical and Mental Health) model was developed for the QLQ‐C30.