CCR5 deficiency/CCR5Δ32: resistant to HIV infection at the cost of curtailed CD4+ T cell memory responses. (8th July 2020)

• Record Type: Journal Article
• Authors: Matti, Christoph; Legler, Daniel F
• Is Part Of: EMBO journal. Volume 39:Number 15(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-07-08
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2020105854
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Orchestrated trafficking and activation by pathogen‐derived peptides define the ability of CD4 + T helper cells to contribute to an effective adaptive immunity. In this issue of The EMBO Journal, Martín‐Leal et al show that the inflammatory chemokine receptor CCR5, well known for its role in cell migration and HIV infection, regulates ceramide synthesis and TCR nanoclustering to promote memory CD4 + T cell activation. Abstract : Regulation of memory T cell functions by the chemokine receptor and HIV‐1 co‐receptor CCR5 in mice may explain why HIV‐1‐resistant CCR5Δ32‐expressing patients are more prone to fatal infections.