Pelvic Reirradiation Utilizing Pulsed Low-dose Rate Radiation Therapy. (October 2020)

• Record Type: Journal Article
• Authors: Paly, Jonathan J.; Deng, Mengying; Lee, Charles T.; Hayes, Shelly B.; Galloway, Thomas J.; Hallman, Mark A.; Weiss, Stephanie E.; Horwitz, Eric M.; Price, Robert A.; Ma, C-M Charlie; Meyer, Joshua E.
• Is Part Of: American journal of clinical oncology. Volume 43:Number 10(2020)
• Publication Date: 2020-10
• Subjects: reirradiation -- retreatment -- pelvic radiotherapy -- pulsed low-dose rate -- recurrent cancer; Cancer -- Treatment -- Periodicals; Oncology -- Periodicals; Tumors -- Periodicals; 616.994005
• DOI: 10.1097/COC.0000000000000741
• Languages: English
• ISSNs: 0277-3732

Abstract

Abstract : Pulsed low-dose rate radiation therapy has been shown to reduce normal tissue damage while decreasing DNA damage repair in tumor cells. In a cohort of patients treated with palliative or definitive pelvic reirradiation using pulsed low-dose rate radiation therapy, we observed substantial local control and low rates of toxicity.