Association of fast ripples on intracranial EEG and outcomes after epilepsy surgery. (20th October 2020)

• Record Type: Journal Article
• Authors: Nevalainen, Päivi; von Ellenrieder, Nicolás; Klimeš, Petr; Dubeau, François; Frauscher, Birgit; Gotman, Jean
• Is Part Of: Neurology. Volume 95:Number 16(2020)
• Publication Date: 2020-10-20
• Subjects: Neurology -- Periodicals; Neurology -- Periodicals; Neurologie -- Périodiques; 616.8
• DOI: 10.1212/WNL.0000000000010468
• Languages: English
• ISSNs: 0028-3878

Abstract

Abstract : Objective: To examine whether fast ripples (FRs) are an accurate marker of the epileptogenic zone, we analyzed overnight stereo-EEG recordings from 43 patients and hypothesized that FR resection ratio, maximal FR rate, and FR distribution predict postsurgical seizure outcome. Methods: We detected FRs automatically from an overnight recording edited for artifacts and visually from a 5-minute period of slow-wave sleep. We examined primarily the accuracy of removing ≥50% of total FR events or of channels with FRs to predict postsurgical seizure outcome (Engel class I = good, classes II–IV = poor) according to the whole-night and 5-minute analysis approaches. Secondarily, we examined the association of low overall FR rates or absence or incomplete resection of 1 dominant FR area with poor outcome. Results: The accuracy of outcome prediction was highest (81%, 95% confidence interval [CI] 67%–92%) with the use of the FR event resection ratio and whole-night recording (vs 72%, 95% CI 56%–85%, for the visual 5-minute approach). Absence of channels with FR rates >6/min ( p = 0.001) and absence or incomplete resection of 1 dominant FR area ( p < 0.001) were associated with poor outcome. Conclusions: FRs are accurate in predicting epilepsy surgery outcome at the individual level when overnight recordings are used. Absence of channels with high FR rates or absence of 1 dominant FR area is a poor prognostic factor that may reflect suboptimal spatial sampling of the epileptogenic zone or multifocality, rather than an inherently low sensitivity of FRs. Classification of evidence: This study provides Class II evidence that FRs are accurate in predicting epilepsy surgery outcome.