The Epidemiology of Pancreatic Cancer and the Association With Acetylsalicylic Acid in the United States: A Population-Based Study. Issue 9 (October 2020)

• Record Type: Journal Article
• Authors: Khoudari, George; Alkhayyat, Motasem; Abou Saleh, Mohannad; Mansoor, Emad; Sarmini, Muhammad Talal; Baidoun, Firas; Vega, Kenneth J.; Sanaka, Madhusudhan R.
• Is Part Of: Pancreas. Volume 49:Issue 9(2020)
• Publication Date: 2020-10
• Subjects: pancreatic cancer -- prevalence of PaC -- aspirin -- acetylsalicylic acid -- ASA -- PaC - pancreatic cancer -- ASA - acetylsalicylic acid -- BMI - body mass index -- SNOMED-CT - Systemized Nomenclature of Medicine—Clinical Terms -- OR - odds ratio -- CI - confidence interval; Pancreas -- Diseases -- Periodicals; Pancreas -- Periodicals; Neuroendocrine tumors -- Periodicals; 616.37005
• DOI: 10.1097/MPA.0000000000001659
• Languages: English
• ISSNs: 0885-3177

Abstract

Abstract : Objectives: Pancreatic cancer (PaC) is the third leading cause of cancer-related death in the United States. Multiple studies have investigated the epidemiology and the association between PaC and acetylsalicylic acid (ASA) use, revealing mixed results. Using a large database, we sought to investigate the epidemiology of PaC. Methods: Using a commercial database (Explorys Inc, Cleveland, Ohio), which includes electronic health record data from 26 major integrated US health care systems, all patients 18 years and older diagnosed with PaC for 5 years were identified based on Systematized Nomenclature Of Medicine—Clinical Terms. We determined the prevalence of PaC and the potential associated factors using univariable and multivariable analysis. Results: Of the 32, 970, 850 individuals, we identified 30, 250 individuals with PaC with an overall prevalence of 0.08%. Individuals with PaC were more likely to be males, seniors (age, >65 years), and White, compared with patients without PaC. In subgroup analysis of chronic pancreatitis, individuals on ASA, individuals >65 years, White, and White males were less likely to have PaC, and non-White females were more likely to have PaC. Conclusions: This is the largest population-based study evaluating the epidemiology of PaC. We observed a protective association of ASA on a subgroup of patients with PaC and chronic pancreatitis.