Chordoma of the Clivus and Acute Myeloid Leukemia: Is There a Connection?. Issue 7 (October 2020)

• Record Type: Journal Article
• Authors: Larkin, Trisha; Macak, Rachel; Lagmay, Joanne; Horn, Biljana
• Is Part Of: Journal of pediatric hematology/oncology. Volume 42:Issue 7(2020)
• Publication Date: 2020-10
• Subjects: chordoma -- acute myeloid leukemia -- cancer predisposition syndrome -- CBFB mutation -- MYH11 mutation -- secondary malignancies; Pediatric hematology -- Periodicals; Tumors in children -- Periodicals; 618.9215
• DOI: 10.1097/MPH.0000000000001659
• Languages: English
• ISSNs: 1077-4114

Abstract

Abstract : Chordoma is a rare cancer in children and understanding the genesis of this tumor may contribute to treatment approaches. Evidence has proposed VDC/IE (vincristine, doxorubicin, cyclophosphamide/ifosfamide, etoposide) as a treatment option for young patients with chordoma to avoid the long-term effects of radiation therapy. We present a case of acute myeloid leukemia developing during treatment of localized chordoma of the clivus in a 20-month-old male. We propose a genomic relationship that may have contributed to the development of clival chordoma and acute myeloid leukemia without a latency period and advocate for genomic sequencing in children with chordoma before the initiation of systemic therapies.