Maternal Microbiome and Metabolic Health Program Microbiome Development and Health of the Offspring. (October 2019)

• Record Type: Journal Article
• Authors: Calatayud, Marta; Koren, Omry; Collado, Maria Carmen
• Is Part Of: Trends in endocrinology and metabolism. Volume 30:Number 10(2019)
• Page Start: 735
• Page End: 744
• Publication Date: 2019-10
• Subjects: microbiota -- nutrition -- lactation -- C-section -- antibiotic -- obesity -- diabetes -- neonatal health; Endocrinology -- Periodicals; Metabolism -- Periodicals; Metabolism; 616.4
• DOI: 10.1016/j.tem.2019.07.021
• Languages: English
• ISSNs: 1043-2760

Abstract

Abstract : Maternal nutritional, metabolic, and physiological states, as well as exposure to various environmental factors during conception, gestation, and lactation, have a fundamental role in the health programming of the offspring. Therefore, alterations affecting the maternal microbiota might indirectly influence fetal development. In addition, such alterations could be transmitted to the progeny at different stages of infant development (e.g., preconception, prenatal, or postnatal), thereby favoring the development of an altered microbiota in the neonate. Microbial changes of this kind have been linked to an increased risk of non-communicable diseases (NCDs), including obesity and metabolic syndrome, allergy-related problems, and diabetes. In this review, we summarize the relevance of the maternal microbiota to fetal–neonatal health programming, with a focus on maternal nutritional and metabolic states. Highlights: Shifts in the maternal microbiota could influence fetal development, in addition to being transmitted to the newborn during birth and lactation. Alterations in microbial colonization patterns are linked to an increased risk of NCDs, such as obesity, diabetes, and allergies. The delivery mode, nutritional status of the mother, and perinatal environmental exposures all impact the gut microbiota, thereby affecting the nutritional and metabolic status of the host. Maternal metabolic status and diet during pregnancy have a key impact on both the maternal and infant microbiota, although the detailed effects remain obscure.