Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus. (October 2020)

• Record Type: Journal Article
• Authors: Chojnacka, K.; Witek-Krowiak, A.; Skrzypczak, D.; Mikula, K.; Młynarz, P.
• Is Part Of: Journal of functional foods. Volume 73(2020)
• Publication Date: 2020-10
• Subjects: Plant extracts -- Phytochemicals -- Bioactivity -- Polyphenols -- Antiviral -- Pandemic -- Coronavirus; 3CLpro 3C-like protease -- ACE2 Angiotensin-converting enzyme 2 -- CBE CBM, Herbal extracts from Rhizoma Cibotii -- CC50 50% cytotoxicity concentration -- CDC Cholesterol-dependent cytolysin -- Covid-19 Coronavirus Disease 2019 -- CPE Cytopathogenic effect -- CTH Herbal extract from Cassiae Semen -- DBM Herbal extract from Dioscoreae Rhizoma -- DNA Deoxyribonucleic acid -- EC50 50% effective concentration -- FA Fatty acid -- FFA Free fatty acid -- GCG Gallocatechin gallate -- GSH Herbal extract from Gentianae Radix -- IC50 50% inhibitory concentrations -- MERS-CoV Middle East Respiratory Syndrome Coronavirus -- Mpro The major protease -- MNP Marine Natural Product -- MTT test Cytotoxicity test using 3- (4, 5-dimethylthiazol-2-yl) −2, 5-diphenyltetrazolium bromide -- PLpro The papain-like protease -- PLY Pneumolysin -- RNA Ribonucleic acid -- SARS-CoV Severe Acute Respiratory Syndrome coronavirus -- TCH Herbal extract from Loranthi Ramus -- WHO World Health Organization; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.104146
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Plant extracts are a source of phytochemicals useful in the treatment of coronavirus diseases. The advantage of using natural plant extracts is their effectiveness and high safety for patients. Water and ethanol plant extracts contain biologically active substances with antiviral activity. Phytochemicals are natural inhibitors of viral enzymes. Abstract: The outbreak of Covid-19 disease caused by SARS-CoV-19, along with the lack of targeted medicaments and vaccines, forced the scientific world to search for new antiviral formulations. In this review, we describe the current knowledge about plant extracts containing polyphenols that inhibit Covid-19. Many plant-derived natural compounds (polyphenols) might provide a starting point for the research on the use of plant extracts in coronavirus treatment and prevention. Antivirus polyphenolic drugs can inhibit coronavirus enzymes, which are essential for virus replication and infection. This group of natural substances (betulinic acid, indigo, aloeemodine, luteolin, and quinomethyl triterpenoids, quercitin or gallates) is a potential key to designing antiviral therapies for inhibiting viral proteases. The known pharmacophore structures of bioactive substances can be useful in the elaboration of new anti-Covid-19 formulations. The benefit of using preparations containing phytochemicals is their high safety for patients and no side effects.