Immuno-oncology trends: preclinical models, biomarkers, and clinical development. Issue 1 (12th January 2022)

• Record Type: Journal Article
• Authors: Franklin, Maryland Rosenfeld; Platero, Suso; Saini, Kamal S; Curigliano, Giuseppe; Anderson, Steven
• Is Part Of: Journal for immunotherapy of cancer. Volume 10:Issue 1(2022)
• Publication Date: 2022-01-12
• Subjects: immunotherapy -- antigenic modulation -- biomarkers -- tumor -- immune tolerance -- clinical trials as topic; Cancer -- Immunotherapy -- Periodicals; Cancer -- Immunological aspects -- Periodicals; Tumors -- Immunological aspects -- Periodicals; Immunotherapy -- Periodicals; 616.99406105
• DOI: 10.1136/jitc-2021-003231
• Languages: English
• ISSNs: 2051-1426

Abstract

Abstract : The landscape in immuno-oncology (I-O) has undergone profound changes since its early beginnings up through the rapid advances happening today. The current drug development pipeline consists of thousands of potential I-O therapies and therapy combinations, many of which are being evaluated in clinical trials. The efficient and successful development of these assets requires the investment in and utilization of appropriate tools and technologies that can facilitate the rapid transitions from preclinical evaluation through clinical development. These tools include (i) appropriate preclinical models, (ii) biomarkers of pharmacodynamic, predictive and monitoring utility, and (iii) evolving clinical trial designs that allow rapid and efficient evaluation during the development process. This article provides an overview of how novel discoveries and insights into each of these three areas have the potential to further address the clinical management needs for patients with cancer.