Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020). Issue 8 (22nd April 2020)

• Record Type: Journal Article
• Authors: Xu, Ziyang; Wise, Megan C.; Chokkalingam, Neethu; Walker, Susanne; Tello‐Ruiz, Edgar; Elliott, Sarah T. C.; Perales‐Puchalt, Alfredo; Xiao, Peng; Zhu, Xizhou; Pumroy, Ruth A.; Fisher, Paul D.; Schultheis, Katherine; Schade, Eric; Menis, Sergey; Guzman, Stacy; Andersen, Hanne; Broderick, Kate E.; Humeau, Laurent M.; Muthumani, Kar; Moiseenkova‐Bell, Vera; Schief, William R.; Weiner, David B.; Kulp, Daniel W.
• Is Part Of: Advanced science. Volume 7:Issue 8(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-04-22
• Subjects: DNA vaccines -- in vivo self‐assembly -- infectious diseases -- nanoparticle vaccines -- protein engineering; Science -- Periodicals; 505
• DOI: 10.1002/advs.202070044
• Languages: English
• ISSNs: 2198-3844

Abstract

Abstract : In article number 1902802, David B. Weiner, Daniel W. Kulp, and co‐workers demonstrate that synthetic DNA delivery and adaptive electroporation can launch de novo assembly of different nanoparticle vaccines in the hosts to elicit significantly improved responses while reducing required doses. Next‐generation designer vaccines can now be rapidly evaluated in vivo to facilitate clinical translation for the betterment of human and animal health.