Release of Amino‐ or Carboxy‐Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design. (6th March 2019)

• Record Type: Journal Article
• Authors: Wei, Peng; Liu, Lingyan; Wen, Ying; Zhao, Guilong; Xue, Fengfeng; Yuan, Wei; Li, Ruohan; Zhong, Yaping; Zhang, Mengfan; Yi, Tao
• Is Part Of: Angewandte Chemie. Volume 131:Number 14(2019)
• Page Start: 4595
• Page End: 4599
• Publication Date: 2019-03-06
• Subjects: Fluoreszenzsonden -- Kontrastmittel -- Krebs -- Reaktive Sauerstoffspezies -- Wirkstofftransport; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201813648
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. The probes can detect HOCl, using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL‐60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly release either amino‐ or carboxy‐containing compounds from prodrugs, during HOCl detection and imaging, to realize a therapeutic effect. Abstract : Dreifache Wirkung : Eine HOCl‐responsive Plattform wurde entwickelt, die Detektion, Bildgebung und Therapiefunktion in sich vereint. Die von dieser Plattform abgeleiteten Sonden können HOCl mittels NIR‐Emission in vitro und in vivo mit hoher Empfindlichkeit und Selektivität nachweisen. Außerdem setzen sie bei der HOCl‐Detektion amino‐ oder carboxyhaltige Verbindungen aus Prodrugs schnell frei, um einen therapeutischen Effekt zu erzielen.