Cover Feature: In Silico Evidence That Protein Unfolding is a Precursor of Protein Aggregation (ChemPhysChem 5/2020). Issue 5 (4th March 2020)

• Record Type: Journal Article
• Authors: Bianco, Valentino; Franzese, Giancarlo; Coluzza, Ivan
• Is Part Of: Chemphyschem. Volume 21:Issue 5(2020)
• Page Start: 358
• Page End: 358
• Publication Date: 2020-03-04
• Subjects: aqueous environments -- computational chemistry -- hydration shell -- protein aggregation -- protein folding; Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.202000092
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract : The Cover Feature illustrates partial unfolding of the native conformation and ultimately complete loss of the folded structures and formation of protein aggregates resulting from increasing the protein concentration in an aqueous environment. The water mediates the partial unfolding with no direct protein‐protein interactions. More information can be found in the Article by V. Bianco et al. on page 377 in Issue 5, 2020 (DOI: 10.1002/cphc.201900904 ).