Respiratory infections regulated blood cells IFN‐β‐PD‐L1 pathway in pediatric asthma. Issue 3 (12th May 2020)

• Record Type: Journal Article
• Authors: Kölle, Julia; Haag, Patricia; Vuorinen, Tytti; Alexander, Kiefer; Rauh, Manfred; Zimmermann, Theodor; Papadopoulos, Nikolaos G.; Finotto, Susetta
• Is Part Of: Immunity, inflammation and disease. Volume 8:Issue 3(2020)
• Page Start: 310
• Page End: 319
• Publication Date: 2020-05-12
• Subjects: human rhinovirus -- IFNβ -- PD‐L1 -- pediatric asthma; Immunology -- Periodicals; Immunity -- Periodicals; Inflammation -- Periodicals; 616.079
• DOI: 10.1002/iid3.307
• Languages: English
• ISSNs: 2050-4527

Abstract

Abstract: Background: Respiratory infections, in general, and rhinovirus infection specifically are the main reason for asthma exacerbation in children and programmed cell death protein 1 ligand (PD‐L1) expression inhibits T cell responses. Objective: Could the interferon (IFN) type I expression in peripheral blood mononuclear cells (PBMCs) improve disease exacerbation in pediatric asthma? Results: Here we found increased level of PD‐L1 messenger RNA (mRNA) in total blood cells isolated from preschool children with virus‐induced asthma, with lower percentage of forced expiratory volume in 1 second and with high serum levels of the C‐reactive‐protein. Conclusions and Clinical Relevance: These data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with induced PD‐L1 mRNA expression in blood cells. Further, type I IFN, IFN‐β, a cytokine that is involved in the clearance of infections, was found to be associated with a better lung function in asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation due to suppressing PD‐L1 expression in blood cells. Abstract : Here we found increased level of programmed cell death protein 1 ligand (PD‐L1) messenger RNA (mRNA) in total blood cells isolated from preschool children with virus‐induced asthma, with lower percentage of forced expiratory volume in 1 second (FEV1%) and with high serum levels of the C‐reactive‐protein (CRP). Further, the activation of regulatory elements that induce interferon‐β (IFNβ), a cytokine that is involved in immunity of infections, was found to be associated with better lung function in asthmatic children. Finally, IFN‐β released by peripheral blood mononuclear cells (PBMCs) was found associated with an induced expression of PD‐L1 mRNA in control but no asthmatic children.