Problem-solving in clinical practice: breathing difficulty and muscle weakness following allogeneic haematopoietic stem cell transplantation. Issue 2 (8th September 2020)

• Record Type: Journal Article
• Authors: Albulushi, Bashaer; Thabet, Farah; Alshahwan, Saad; Elborai, Yasser; Alkhayat, Nawaf; Alshahrani, Mohamed; Tabarki, Brahim
• Is Part Of: Archives of disease in childhood. Volume 106:Issue 2(2021)
• Page Start: 125
• Page End: 128
• Publication Date: 2020-09-08
• Subjects: myasthenia gravis -- bone marrow transplant -- graft versus host disease; Pediatrics -- Practice -- Periodicals; Children -- Diseases -- Treatment -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2019-317281
• Languages: English
• ISSNs: 1743-0585

Abstract

Abstract : Acute weakness and dyspnoea are unusual presentation after allogeneic haematopoietic stem cell transplantation (HSCT) complicated by chronic graft-versus-host disease (GVHD). The differential diagnosis and management are challenging for the paediatrician. This case chronicles the diagnostic journey of a child who presented with weakness, dyspnoea and difficulty in speech, 2 years after allogeneic HSCT and GVHD and explores the approach to neurological manifestations in this context.