Anti bacterial and anticancer activities of quinoxaline-2-carbohydrazide-N-oxide compounds. (2022)

• Record Type: Journal Article
• Authors: Ketha, Swarupa; Kethireddy, Shashikala; Chithaluri, Sudhakar; Eppakayala, Laxminarayana
• Is Part Of: Materials today. Volume 49:Part 5(2022)
• Page Start: 1804
• Page End: 1809
• Publication Date: 2022
• Subjects: Cytotoxic -- Di N-oxides -- Hypoxia -- MTT assay -- O-Phenylenediamine; Materials science -- Congresses -- Periodicals; 620.1
• DOI: 10.1016/j.matpr.2021.08.023
• Languages: English
• ISSNs: 2214-7853

Abstract

Abstract: A series of quinoxaline 1, 4-di- N -oxide derivatives, which have been proven to be active cytotoxic agents under hypoxic conditionswere synthesized. Ethyl-3-hydroxyquinoxaline-2-carboxylate (1 ) on reaction with hydrazine hydrate in ethanol yielded 3-hydroxyquinoxaline-2-carbohydrazide(2 ). This product on condensation with different aromatic aldehydes yielded N -4-bromobenzylidine)-3-hydroxyquinoxaline-2-carbohydrazide(3 ) which upon reaction with mCPBA in THF resulted in the abovementionedproducts. These derivatives were evaluated for theiranti-bacterial activity using four different strains. A few compounds among them were also evaluated for their anti-tumour activity towards breast cancer (MCF7) and cervical cancer (HeLa) cell lines. Compound 4a showed moderate activity towards breast cancer cell lines (MCF7) and 4b towards cervical cancer cell lines ( HeLa) . All the compounds were characterized by IR, 1 H NMR and Mass spectroscopy.