Microfluidics in Malignant Glioma Research and Precision Medicine. Issue 5 (2nd April 2018)

• Record Type: Journal Article
• Authors: Logun, Meghan; Zhao, Wujun; Mao, Leidong; Karumbaiah, Lohitash
• Is Part Of: Advanced biosystems. Volume 2:Issue 5(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-04-02
• Subjects: glioblastoma -- in vitro diagnostic devices -- microfluidics; Biological systems -- Periodicals; Biotechnology -- Periodicals; Bioengineering -- Periodicals; Biomedical engineering -- Periodicals; Biological Science Disciplines; Periodicals; Periodicals; 660.6
• DOI: 10.1002/adbi.201700221
• Languages: English
• ISSNs: 2366-7478

Abstract

Abstract: Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that has no effective treatments and a prognosis of only 12–15 months. Microfluidic technologies deliver microscale control of fluids and cells, and have aided cancer therapy as point‐of‐care devices for the diagnosis of breast and prostate cancers. However, a few microfluidic devices are developed to study malignant glioma. The ability of these platforms to accurately replicate the complex microenvironmental and extracellular conditions prevailing in the brain and facilitate the measurement of biological phenomena with high resolution and in a high‐throughput manner could prove useful for studying glioma progression. These attributes, coupled with their relatively simple fabrication process, make them attractive for use as point‐of‐care diagnostic devices for detection and treatment of GBM. Here, the current issues that plague GBM research and treatment, as well as the current state of the art in glioma detection and therapy, are reviewed. Finally, opportunities are identified for implementing microfluidic technologies into research and diagnostics to facilitate the rapid detection and better therapeutic targeting of GBM. Abstract : Current challenges and emerging opportunities related to the use of microfluidics‐based technologies for glioblastoma multiforme (GBM) research and diagnostics are discussed.