Green seaweeds ulvan-cellulose scaffolds enhance in vitro cell growth and in vivo angiogenesis for skin tissue engineering. (1st January 2021)

• Record Type: Journal Article
• Authors: Madub, Koushanee; Goonoo, Nowsheen; Gimié, Fanny; Ait Arsa, Imade; Schönherr, Holger; Bhaw-Luximon, Archana
• Is Part Of: Carbohydrate polymers. Volume 251(2021)
• Publication Date: 2021-01-01
• Subjects: Ulva sp. -- Cellulose -- Ulvans -- Nanofibrous scaffolds -- Tissue engineering; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.117025
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: Cellulose extracted from ulva seaweeds contains ulvans. Ulvan cellulose accelerated fibroblasts growth for tissue regeneration. In vivo angiogenesis is promoted by ulvan cellulose nanofibrous mats. Abstract: Cellulose has been extracted from a wide range of land resources, whereas it has been scarcely exploited from marine resources. Cellulose from green seaweeds can be extracted together with smaller molecules called ulvans. We have successfully extracted and characterized cellulose from Ulva sp. Solid state 13 C NMR indicated the presence of ulvans in the cellulose extracts. The extracted cellulose was blended with polylactide and polydioxanone and electrospun into nanofibrous mats with a range of physico-chemical properties. These cellulose-based scaffolds were assessed in vitro using fibroblast cells and showed accelerated cell growth. In vivo biocompatibility studies using a Wistar rat model indicated the absence of foreign body response and enhanced angiogenesis.