Targeted Approaches for In Situ Gut Microbiome Manipulation. Issue 4 (6th February 2020)

• Record Type: Journal Article
• Authors: Cresci, Gail A. M.; Lampe, Johanna W.; Gibson, Glenn
• Is Part Of: JPEN, Journal of parenteral and enteral nutrition. Volume 44:Issue 4(2020)
• Page Start: 581
• Page End: 588
• Publication Date: 2020-02-06
• Subjects: alcohol -- diet -- gut microbiome -- gut microbiota -- human studies -- prebiotics -- probiotics -- synbiotics; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; 615.85484
• DOI: 10.1002/jpen.1779
• Languages: English
• ISSNs: 0148-6071

Abstract

Abstract: The 2019 Dudrick Research Symposium, entitled "Targeted Approaches for In Situ Gut Microbiome Manipulation, " was held on March 25, 2019, at the American Society for Parenteral and Enteral Nutrition (ASPEN) 2019 Nutrition Science & Practice Conference in Phoenix, AZ. The Dudrick Symposium honors the many pivotal and innovative contributions to the development and advancement of parenteral nutrition (PN) made by Dr Stanley J. Dudrick, physician scientist, academic leader, and a founding member of ASPEN. As the 2018 recipient of the Dudrick award, Dr Gail Cresci organized and chaired the symposium. The symposium addressed the evolving field of nutrition manipulation of the gut microbiome as a means to mitigate disease and support health. Presentations focused on (1) the role of prebiotics as a means to beneficially support gut microbiome composition and function and health; (2) designer synbiotics targeted to support metabolic by‐products altered by ethanol exposure and microbial effectors that manipulate host metabolic outcomes; and, lastly, (3) types of intervention designs used to study diet–gut microbiome interactions in humans and a review of findings from recent interventions, which tested the effects of diet on the microbiome and the microbiome's effect on dietary exposures. New molecular techniques and multiomic approaches have improved knowledge of the structure and functional activity of the gut microbiome; however, challenges remain in establishing causal relationships between changes in the gut microbial–community structure and function and health outcomes in humans.