The diverse roles of adiponectin in non-small-cell lung cancer: current data and future perspectives. (August 2015)

• Record Type: Journal Article
• Authors: Boura, Paraskevi; Loukides, Stylianos; Grapsa, Dimitra; Achimastos, Apostolos; Syrigos, Konstantinos
• Is Part Of: Future oncology. Volume 11:Number 15(2015)
• Page Start: 2193
• Page End: 2203
• Publication Date: 2015-08
• Subjects: adipokines -- adiponectin -- adipose tissue -- cancer cachexia -- non-small-cell lung cancer; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.15.96
• Languages: English
• ISSNs: 1479-6694

Abstract

In recent years, there is growing research interest for the biological role of adipose tissue-derived bioactive factors, mainly including adipokines, in various forms of cancer. Adiponectin (APN) is the most abundant circulating adipokine, and a key mediator of several cancer-related processes, such as cell proliferation, apoptosis, regulation of tumor cell invasion and angiogenesis. In this review we summarize and critically discuss the published literature on the diverse roles of APN in non-small-cell lung cancer, including its implication in lung cancer development, its use as a diagnostic and prognostic biomarker, and its correlation with cancer-related cachexia. The main challenges and future perspectives, mainly with regard to the potential development of APN-targeted therapeutic agents in cancer therapeutics, are also briefly presented and discussed.