Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential. (March 2015)

• Record Type: Journal Article
• Authors: Chu, Tianci; Zhou, Hengxing; Lu, Lu; Kong, Xiaohong; Wang, Tianyi; Pan, Bin; Feng, Shiqing
• Is Part Of: Regenerative medicine. Volume 10:Number 2(2015)
• Page Start: 193
• Page End: 209
• Publication Date: 2015-03
• Subjects: animal model -- clinical trial -- GSK-3 inhibitor -- HDAC inhibitor -- neurogenesis -- neuroprotection -- secondary injury -- spinal cord injury -- valproic acid; Cellular therapy -- Periodicals; Stem cells -- Transplantation -- Periodicals; Degeneration (Pathology) -- Treatment -- Periodicals; Regeneration (Biology) -- Periodicals; 611.018
• DOI: 10.2217/rme.14.86
• Languages: English
• ISSNs: 1746-0751

Abstract

Spinal cord injury (SCI) is difficult to treat because of secondary injury. Valproic acid (VPA) is clinically approved for mood stabilization, but also counteracts secondary damage to functionally rescue SCI in animal models by improving neuroprotection and neurogenesis via inhibition of HDAC and GSK-3. However, a comprehensive review summarizing the therapeutic benefits and mechanisms of VPA for SCI and the issues affecting clinical trials is lacking, limiting future research on VPA and impeding its translation into clinical therapy for SCI. This article presents the current status of VPA treatment for SCI, emphasizing interactions between enhanced neuroprotection and neurogenesis. Crucial issues are discussed to optimize its clinical potential as a safe and effective treatment for SCI.