Chemical diversity and anti-proliferative activity of marine algae. Issue 14 (18th July 2019)

• Record Type: Journal Article
• Authors: Palanisamy, Satheesh Kumar; Arumugam, Velusamy; Rajendran, Samyutha; Ramadoss, Anandhan; Nachimuthu, Subash; Peter D., Magesh; Sundaresan, Umamaheswari
• Is Part Of: Natural product research. Volume 33:Issue 14(2019)
• Page Start: 2120
• Page End: 2124
• Publication Date: 2019-07-18
• Subjects: Seaweeds -- GC-MS -- metabolites -- metabolomics -- chemotaxonomy -- anti-bacterial -- anti-proliferative -- HeLa cells; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2018.1488701
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: The chemical diversity of three macroalgae ( Ulva reticulata, Sargassum wightii, Gracilaria sp) were determined using the GC-MS method with principal component analysis (PCA) and their potential efficacy against human pathogens and cervical carcinoma cells evaluated using MTT bioassay method. Our results showed that >30 metabolites were detected in three seaweeds, among these, steroids and fatty acids are the most dominant chemical group that highly contributes to discriminate this species. The PCA of GC-MS mass spectral variables showed a clear discrimination between three different species based on the phytochemical diversity of seaweeds. The extracts of U. reticulata exhibited anti-microbial activity with Pseudomonas aeruginosa (6.00 mm) and showed potential anti-proliferative activity against the HeLa cells (IC50 37 µmol/L) at concentration 1–50 µM treatment. Results of this study concluded that PCA analysis of mass spectral variables could be utilized as a reliable tool for species discrimination and chemotaxonomic classification of seaweeds. Abstract :