Pharmacokinetics of intravenous and oral metformin and r, s-verapamil in Sinclair, Hanford, Yucatan and Göttingen minipigs. (May 2017)

• Record Type: Journal Article
• Authors: Patel, Nita J; Yumibe, Nathan; Ruterbories, Kenneth; Huang, Naijia; Burns, Lee; Tan, Jeffrey; White, David; Liu, Jason; Brocksmith, Derek; Bouchard, Guy; Stricker-Krongrad, Alain
• Is Part Of: International journal of pharmacokinetics. Volume 2:Number 2(2017)
• Page Start: 81
• Page End: 91
• Publication Date: 2017-05
• Subjects: bioavailability -- minipig strains -- minipigs -- pharmacokinetics; Pharmacokinetics -- Periodicals; 615.705
• DOI: 10.4155/ipk-2016-0002
• Languages: English
• ISSNs: 2053-0846

Abstract

Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R, S-verapamil (R, S-VER).Results: The results indicated that the PK of metformin was similar between all minipig strains, except for the Göttingen which had higher plasma clearance. The plasma clearance of both (+)-( R )- and (−)-( S )-VER was significantly lower in Sinclair compared with the clearance in other strains. The (+)-( R )-NOR to R, S-VER ratio was significantly higher in the Sinclair. There was a preferential conversion of R, S-VER to (+)-( R )-NOR over (−)-( S )-NOR in all minipig strains.Conclusion: This work highlights the importance of considering the impact of metabolic and dispositional differences in minipig strains when conducting PK studies.