Knowledge gaps in oncoplastic breast surgery. Issue 8 (August 2020)

• Record Type: Journal Article
• Authors: Weber, Walter P; Morrow, Monica; Boniface, Jana de; Pusic, Andrea; Montagna, Giacomo; Kappos, Elisabeth A; Ritter, Mathilde; Haug, Martin; Kurzeder, Christian; Saccilotto, Ramon; Schulz, Alexandra; Benson, John; Fitzal, Florian; Matrai, Zoltan; Shaw, Jane; Peeters, Marie-Jeanne Vrancken; Potter, Shelley; Heil, Joerg; González, Eduardo; Elzayat, Mona; Koller, Rupert; Gnant, Michael; Brenelli, Fabricio; Paulinelli, Regis Resende; Zobel, Vappu; Joukainen, Sarianna; Karhunen-Enckell, Ulla; Kauhanen, Susanna; Piat, Jean-Marc; Bjelic-Radisic, Vesna; Faridi, Andree; Heitmann, Christoph; Hoffmann, Juergen; Kneser, Ulrich; Kümmel, Sherko; Kühn, Thorsten; Kontos, Michalis; Tampaki, Ekaterini Christina; Barry, Mitchel; Allweis, Tanir M; Carmon, Moshe; Hadar, Tal; Catanuto, Giuseppe; Garcia-Etienne, Carlos A; Gentilini, Oreste D; Knox, Susan; Klein, Barbara; Koppert, Linetta; Gouveia, Pedro F; Svensjö, Tor; Bucher, Heiner C; Ess, Silvia; Ganz-Blättler, Ursula; Günthert, Andreas; Hauser, Nik; Hynes, Nancy; Knauer, Michael; Pfeiffer, Marlen; Rochlitz, Christoph; Tausch, Christoph; Harder, Yves; Zimmermann, Frank; Schwab, Fabienne D; D'Amico, Veronica; Soysal, Savas D; Castrezana Lopez, Liliana; Fulco, Ilario; Hemkens, Lars G; Lohsiriwat, Visnu; Gulluoglu, Bahadir M; Karadeniz, Guldeniz; Karanlik, Hasan; Sezer, Atakan; Gulcelik, Mehmet Ali; Emiroglu, Mustafa; Kovacs, Tibor; Rattay, Tim; Romics, Laszlo; Vidya, Raghavan; Wyld, Lynda; El-Tamer, Mahmoud; Sacchini, Virgilio;
• Is Part Of: Lancet oncology. Volume 21:Issue 8(2020)
• Page Start: e375
• Page End: e385
• Publication Date: 2020-08
• Subjects: Oncology -- Periodicals; Neoplasms -- Periodicals; Cancérologie -- Périodiques; Oncologie; Oncology; Periodicals; Electronic journals; 616.994005
• DOI: 10.1016/S1470-2045(20)30084-X
• Languages: English
• ISSNs: 1470-2045

Abstract

Abstract: The aims of the Oncoplastic Breast Consortium initiative were to identify important knowledge gaps in the field of oncoplastic breast-conserving surgery and nipple-sparing or skin-sparing mastectomy with immediate breast reconstruction, and to recommend appropriate research strategies to address these gaps. A total of 212 surgeons and 26 patient advocates from 55 countries prioritised the 15 most important knowledge gaps from a list of 38 in two electronic Delphi rounds. An interdisciplinary panel of the Oncoplastic Breast Consortium consisting of 63 stakeholders from 20 countries obtained consensus during an in-person meeting to select seven of these 15 knowledge gaps as research priorities. Three key recommendations emerged from the meeting. First, the effect of oncoplastic breast-conserving surgery on quality of life and the optimal type and timing of reconstruction after nipple-sparing or skin-sparing mastectomy with planned radiotherapy should be addressed by prospective cohort studies at an international level. Second, the role of adjunctive mesh and the positioning of implants during implant-based breast reconstruction should ideally be investigated by randomised controlled trials of pragmatic design. Finally, the BREAST-Q questionnaire is a suitable tool to assess primary outcomes in these studies, but other metrics to measure patient-reported outcomes should be systematically evaluated and quality indicators of surgical morbidity should be further assessed.