Insulin given intranasally induces hypoglycaemia in normal and diabetic subjects. Issue 6312 (30th January 1982)

• Record Type: Journal Article
• Authors: Pontiroli, A E; Alberetto, M; Secchi, A; Dossi, G; Bosi, I; Pozza, G
• Is Part Of: BMJ. Volume 284:Issue 6312(1982)
• Page Start: 303
• Page End: 306
• Publication Date: 1982-01-30
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.284.6312.303
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Regular or crystalline insulin with sodium glycocholate as surfactant administered intranasally to normal volunteers induced hypoglycaemia and an increase in serum immunoreactive insulin concentrations. Serum C-peptide concentrations decreased or remained unchanged. Insulin administered intravenously to three of these subjects yielded a potency ratio of 1:8 for intranasal and intravenous insulin. In four insulin-dependent diabetics a cross-over study was performed on different days, insulin being administered once intranasally and once subcutaneously in a ratio of 1:9. In these patients the intranasal insulin was more effective than the subcutaneous insulin in preventing hyperglycaemia after breakfast. In four other insulin-dependent diabetics 11-hours monitoring was performed twice on two different days, insulin being administered in divided dosage sufficient to achieve a reasonable glycaemic profile. The administration during the morning, whereas subcutaneous insulin was more effective than intranasal during the afternoon.