Light-chain nephropathy in patient with renal carcinoma. Issue 6287 (1st August 1981)

• Record Type: Journal Article
• Authors: Enia, G; Maringhini, S; L'Abbate, A; Zoccali, C; Maggiore, Q
• Is Part Of: BMJ. Volume 283:Issue 6287(1981)
• Page Start: 339
• Page End: 340
• Publication Date: 1981-08-01
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.283.6287.339
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Paraneoplastic syndromes are often associated with renal parenchymal tumours. This report describes a case of renal-cell carcinoma with kappa-chain nephropathy. The patient, a 60-year-old man, had renal tubular dysfunction, shown by low serum concentrations of urate and phosphate. Kappa-chains were found in both serum and urine, but no lambda-chains were found. Investigations showed a clear-cell carcinoma, and the patient underwent a radical nephrectomy. Two years after operation serum phosphate and urate concentrations had returned to normal, and kappa-chains were undetectable in serum or urine. The absence of lambda-chains indicates that the light-chain proteinuria was due to overproduction of the M component, and the disappearance of kappa-chains after the operation suggests a causal relation between the renal tumour and the overproduction of the M component.