Rotavirus Vaccine Trials in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b) and Future Use of the Vaccine in Bangladesh. (16th September 2021)

• Record Type: Journal Article
• Authors: Zaman, K; Aziz, Asma Binte; Yunus, Md; Qadri, Firdausi; Ross, Allen G; Clemens, John D
• Is Part Of: Journal of infectious diseases. Volume 224:Supplement 7(2021)
• Page Start: S801
• Page End: S804
• Publication Date: 2021-09-16
• Subjects: Bangladesh -- efficacy study -- rotavirus vaccine; Communicable diseases -- Periodicals; Diseases -- Causes and theories of causation -- Periodicals; Medicine -- Periodicals; Communicable Diseases -- Periodicals; Electronic journals; 616.9
• DOI: 10.1093/infdis/jiab442
• Languages: English
• ISSNs: 0022-1899

Abstract

Abstract: Safe and effective rotavirus vaccines (RVs) are needed to reduce the enormous public health burden of rotavirus illness in developing countries. Vaccination is critical for effective control of rotavirus infection since it cannot be prevented with improvements in water and sanitation. The International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b) has completed several groundbreaking RV trials (Phase I–Phase IV). The safety, immunogenicity, efficacy, and effectiveness of different RVs were evaluated among both urban and rural populations. In this study, we present the results, policy implications, and lessons learned for successful implementation of these trials as well as future directions for rotavirus vaccination in Bangladesh.