MYC Expression Is Associated With p53 Expression and TP53 Aberration and Predicts Poor Overall Survival in Acute Lymphoblastic Leukemia/Lymphoma. Issue 1 (16th September 2021)

• Record Type: Journal Article
• Authors: Gao, Linlin; Harbaugh, Brent; Parr, Kevin; Patel, Payal; Golem, Shivani; Zhang, Da; Woodroof, Janet; Cui, Wei
• Is Part Of: American journal of clinical pathology. Volume 157:Issue 1(2022)
• Page Start: 119
• Page End: 129
• Publication Date: 2021-09-16
• Subjects: MYC -- MYC -- p53 -- TP53 -- cute lymphoblastic leukemia -- Lymphoblastic lymphoma; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqab105
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: We evaluated MYC and p53 expression, TP53 aberration, their relationship, and their impact on overall survival (OS) in acute lymphoblastic leukemia (ALL)/lymphoblastic lymphoma (LBL). Methods: We identified 173 patients with ALL and LBL, including 12 cases of mixed-phenotype acute leukemia, 8 cases of therapy-related B-cell ALL (B-ALL), 119 cases of B-ALL, and 34 cases of T-cell ALL/LBL diagnosed from 2003 to 2019. We retrospectively assessed p53 and MYC expression by immunohistochemistry of bone marrow and correlated MYC expression with p53 expression and TP53 aberration. Results: Expression of p53 and MYC was present in 11.5% and 27.7% of ALL/LBL cases (n = 20 and n = 48), respectively. MYC expression was significantly correlated with p53 expression and TP53 aberration ( P = .002 and P = .03), and p53 expression and MYC expression had an adverse impact on OS in patients with ALL/LBL ( P < .05). MYC and p53 dual expression as well as combined MYC expression and TP53 aberration had a negative impact on OS in patients with ALL/LBL. Conclusions: MYC expression is correlated with p53 overexpression, TP53 aberration, and poor OS in patients with ALL/LBL.