Clinicopathologic Findings in Patients With Initial Diagnosis of Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT) in Colorectal Mucosa. Issue 1 (31st August 2021)

• Record Type: Journal Article
• Authors: Soma, Lorinda A; Smith, Stephen D; Reddy, Prathima; Edlefsen, Kerstin L; Wu, David; Cherian, Sindhu; Chen, Xueyan; Zhou, Yi; Reddi, Deepti; Fromm, Jonathan R
• Is Part Of: American journal of clinical pathology. Volume 157:Issue 1(2022)
• Page Start: 23
• Page End: 32
• Publication Date: 2021-08-31
• Subjects: Colon -- Rectal -- MALT -- Incidental -- Lymphoma -- Lymphoproliferative disorder; Diagnosis, Laboratory -- Periodicals; Pathology -- Periodicals; 616.07
• DOI: 10.1093/ajcp/aqab089
• Languages: English
• ISSNs: 0002-9173

Abstract

Abstract: Objectives: To evaluate clinicopathologic features, management, and behavior of colorectal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). Methods: Clinical data, laboratory studies, and radiographic records were reviewed (2005-2018), and fluorescence in situ hybridization studies were performed. Results: Eleven patients were identified, six of whom were discovered as an incidental finding on endoscopy. Morphologic and immunophenotypic features were similar to MALT lymphomas at other sites except that lymphoepithelial lesions were uncommon. Three of nine patients were positive for BIRC3/MALT1 fusions, two of whom had identical B-cell clones identified in subsequent gastric biopsy specimens. Eight of 10 patients had no clinically evaluable disease after observation (±antibiotics; n = 4) or radiation/chemotherapy (n = 4). Conclusions: Patients with incidental and localized colonic MALT lymphoma demonstrated an excellent prognosis with conservative management, although longer follow-up and data based on consistent staging and surveillance methods (including gastric evaluation) are necessary for informed management.