Molecular Changes in the Dorsal Root Ganglion during the Late Phase of Peripheral Nerve Injury–induced Pain in Rodents: A Systematic Review. (29th December 2021)

• Record Type: Journal Article
• Authors: Chalaki, Mehrman; Cruz, Luis J.; van Neerven, Sabien G. A.; Verhaagen, Joost; Dahan, Albert; Malessy, Martijn J. A.
• Is Part Of: Anesthesiology. Volume 136:Number 2(2022)
• Page Start: 362
• Page End: 388
• Publication Date: 2021-12-29
• Subjects: Anesthesiology -- Periodicals; Anesthetics -- Periodicals; Anesthesia -- Periodicals; 617.9605
• DOI: 10.1097/ALN.0000000000004092
• Languages: English
• ISSNs: 0003-3022

Abstract

Abstract : The dorsal root ganglion is widely recognized as a potential target to treat chronic pain. A fundamental understanding of quantitative molecular and genomic changes during the late phase of pain is therefore indispensable. The authors performed a systematic literature review on injury-induced pain in rodent dorsal root ganglions at minimally 3 weeks after injury. So far, slightly more than 300 molecules were quantified on the protein or messenger RNA level, of which about 60 were in more than one study. Only nine individual sequencing studies were performed in which the most up- or downregulated genes varied due to heterogeneity in study design. Neuropeptide Y and galanin were found to be consistently upregulated on both the gene and protein levels. The current knowledge regarding molecular changes in the dorsal root ganglion during the late phase of pain is limited. General conclusions are difficult to draw, making it hard to select specific molecules as a focus for treatment. Abstract : This article reviews the current literature regarding the quantitative molecular changes in the dorsal root ganglion during the late phase (defined as survival times of 3 weeks or longer) of peripheral nerve injury–induced pain in rodents. Supplemental Digital Content is available in the text.