Exercise heart rates at different serum digoxin concentrations in patients with atrial fibrillation. Issue 6461 (5th January 1985)

• Record Type: Journal Article
• Authors: Beasley, R; Smith, D A; McHaffie, D J
• Is Part Of: BMJ. Volume 290:Issue 6461(1985)
• Page Start: 9
• Page End: 11
• Publication Date: 1985-01-05
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.290.6461.9
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Heart rate at rest and during increasing workloads was measured in a double blind study of 12 patients with chronic atrial fibrillation when serum concentrations of digoxin were nil and at low and high therapeutic values. Twelve normal subjects were studied for comparison. The heart rate at all levels of exercise in most patients with atrial fibrillation was not adequately controlled by any serum digoxin concentration tested despite a reduction in heart rate with increasing serum digoxin concentrations. Control of the resting heart rate, even in patients with high serum digoxin concentrations, did not ensure adequate control of the heart rate during work rates equivalent to regular daily activities.