Peptides as 3D printable feedstocks: Design strategies and emerging applications. (January 2022)

• Record Type: Journal Article
• Authors: Murphy, Robert D.; Garcia, Ronnie V.; Heise, Andreas; Hawker, Craig J.
• Is Part Of: Progress in polymer science. Volume 124(2022)
• Publication Date: 2022-01
• Subjects: Peptides -- Polypeptides -- Polymers -- Hydrogels -- Crosslinking -- 3D printing; 3D three-dimensional -- A alanine -- AcAc acetyl acetone -- AAm acrylamide -- Ag NPs silver nanoparticles -- AM additive manufacturing -- BSA bovine serum albumin -- C cysteine -- CA4 combretastatin -- CAD computer aided design -- CNS central nervous system -- D aspartic acid -- DCH diblock copolypeptide hydrogels -- DIW direct ink writing -- DLP digital light processing -- DMD digital micromirror device -- DoD droplet-on-demand -- DOX doxorubicin -- dsDNA double stranded DNA -- E lutamic acid; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2021.101487
• Languages: English
• ISSNs: 0079-6700

Abstract

Abstract: Peptide hydrogels have proven to be a critical building block for a range of scientific applications due to their high water capacity, tunable mechanical properties, and modular synthetic design. Particular interest stems from the biomedical realm due to their inherent biomimetic structure and biocompatibility, which has prompted their use as 3D printable matrices. In this review, we will discuss the two main strategies for preparing peptide hydrogels using solid-phase peptide synthesis (SPPS) and N -carboxyanhydride ring opening polymerization (NCA ROP) to construct the linear chains followed by gelation through either non-covalent interactions or covalent crosslinking using light or enzymes as a trigger. These synthetic approaches are summarized with a view to the applicability of hydrogel building blocks in 3D printing and representative examples illustrating the future outlook and possible research directions for the field. Graphical abstract: Image, graphical abstract