Activatable peptide-based nanoprobes for multimodal imaging in vivo. (8th October 2021)

• Record Type: Journal Article
• Authors: Zhou, Yanyan; Shen, Xiaochen; Cao, Yi
• Is Part Of: Nano express. Volume 2:Number 4(2021)
• Publication Date: 2021-10-08
• Subjects: peptide -- nanoprobe -- multimodal -- in vivo imaging -- self-assembly; Nanotechnology -- Periodicals; Nanoscience -- Periodicals; 620.5
• DOI: 10.1088/2632-959X/ac2a8e
• Languages: English
• ISSNs: 2632-959X

Abstract

Abstract: Multimodal imaging is considered as an important and promising tool for clinical diagnosis and therapy monitoring. Owing to their inherent characteristics such as excellent biocompatibility, biodegradability, and low immunogenicity, peptides have been extensively explored for the construction of multimodal imaging nanoprobes. In particular, by utilizing valuable endogenous triggers, a number of activable peptide-based nanoprobes have been developed for efficient multimodal imaging in vivo . In this Perspective, we will discuss a few valuable endogenous stimuli that can be used for the design of in situ activable nanoprobes and highlight recent advances in peptide-based nanoprobes for multimodal imaging in vivo . Moreover, some brief and personal opinions on remaining challenges in this field are presented. We envision that this perspective article may inspire for the design of intelligent activatable peptide-based multimodal nanoprobes.