Astrocytes regulate action potential propagation in myelinated axons: It is very crowded at the node of Ranvier. (January 2022)

• Record Type: Journal Article
• Authors: Butt, Arthur M; Verkhratsky, Alexei
• Is Part Of: Cell calcium. Volume 101(2022)
• Publication Date: 2022-01
• Subjects: AP action potential -- AR adenosine receptor -- ATP adenosine triphosphate -- GM grey matter -- HCN hyperpolarisation-activated cyclic nucleotide–gated channel -- K2P leak K+ channel -- Kir inward rectifier K+ channel -- Kv voltage-gated K+ channel -- Nav voltage-gated Na+ channel -- P2R purine receptor -- WM white matter; Fibrous astrocyte -- Node of Ranvier -- Excitability -- Purinoceptors -- Axoglial signalling complex; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2021.102518
• Languages: English
• ISSNs: 0143-4160

Abstract

Highlights: Astrocytes regulate action potential propagation in myelinated axons of CNS white matter. Astrocyte-axon integration through purinergic (ATP and adenosine) signalling. Astrocyte Ca 2+ signalling triggers their release of ATP which is converted to adenosine. Activation of A2A receptors regulate axonal excitability through HCN channels. Hence, astrocytes modify WM information flow and neural circuit function in pathways that regulate all facets of brain and bodily functions.