Subacute sclerosing panencephalitis: detection of measles virus RNA in appendix lymphoid tissue before clinical signs. Issue 6546 (30th August 1986)

• Record Type: Journal Article
• Authors: Fournier, J G; Lebon, P; Bouteille, M; Goutieres, F; Rozenblatt, S
• Is Part Of: BMJ. Volume 293:Issue 6546(1986)
• Page Start: 523
• Page End: 524
• Publication Date: 1986-08-30
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.293.6546.523
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : An appendix removed 15 days before onset of symptoms of subacute sclerosing panencephalitis was examined retrospectively for measles virus ribonucleic acid (RNA). Tissue sections hybridised in situ to a cloned measles virus probe of deoxyribonucleic acid specific for nucleocapsid protein showed that many cells of the lymphoid tissue contained measles virus RNA. In contrast, only a few infected lymphoid cells were detected in three out of six seropositive controls and none in three seronegative infants. A widespread chronic viral infection of the immune system, established after measles, may promote or even initiate nerve cell infection in subacute sclerosing panencephalitis.