Bis‐cyclometalated Rhodium and Iridium Chloride Complexes Yield Different Products Upon Reaction With 9, 10‐Diaminophenanthrene. Issue 17 (29th August 2019)

• Record Type: Journal Article
• Authors: Graf, Marion; Siegmund, Daniel; Metzler‐Nolte, Nils; Sünkel, Karlheinz
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 645:Issue 17(2019)
• Page Start: 1068
• Page End: 1071
• Publication Date: 2019-08-29
• Subjects: Iridium -- Rhodium -- Cyclometalated complexes -- Organometallic anti‐cancer drugs -- Bioorganometallic Chemistry; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.201900147
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract : The reaction of 9.10‐diaminophenanthrene with [{Rh(μ‐Cl)(ptpy)2 }2 ] yields – quite unexpected – the new cyclometalated complex salts [Rh(ptpy)2 (9, 10‐diiminophenanthrene)]PF6 (1 ), whereas with the corresponding dinuclear iridium compound the "usual" [Ir(ptpy)2 (9, 10‐diaminophenanthrene)]PF6 (2 ) is obtained. The molecular structure of compound 1 was confirmed by single‐crystal X‐ray diffraction. 1 crystallized in the monoclinic space group P 21 / n as a dichloromethane solvate. Both compounds display significant cytotoxicity against human cancer cell lines with the IC50 values in the low micromolar range. Abstract :