Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity. (January 2022)

• Record Type: Journal Article
• Authors: Kleftaki, Stamatia-Angeliki; Simati, Stamatia; Amerikanou, Charalampia; Gioxari, Aristea; Tzavara, Chara; Zervakis, Georgios I.; Kalogeropoulos, Nick; Kokkinos, Alexander; Kaliora, Andriana C.
• Is Part Of: Pharmacological research. Volume 175(2022)
• Publication Date: 2022-01
• Subjects: γ-GT γ-glutamyl transferase -- ALP alkaline phospatase -- ALT alanine aminotransferase -- AST aspartate aminotransferase -- AUC Area under the curve -- CRP C-reactive protein -- GLP-1 Glucagon-like peptide-1 -- HDL-C high-density lipoprotein cholesterol -- LDH lactate dehydrogenase -- LDL-C low-density lipoprotein cholesterol -- MetS Metabolic Syndrome -- PYY Peptide YY -- REE Resting energy expenditure -- T2D Type 2 diabetes -- TC total cholesterol -- TG triglyceride -- VAS Visual analogue scales; Pleurotus eryngii -- Postprandial glucose -- Postprandial hormone response -- Appetite -- Polysaccharides -- Beta-glucans; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2021.105979
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: The aim of this study was to examine potential postprandial benefits of Pleurotus eryngii in nineteen volunteers with metabolically unhealthy obesity. An acute, randomized, crossover-designed trial comparing a meal with Pleurotus eryngii and a control meal was performed. The two meals matched in macronutrient and caloric content. Participants consumed both meals in random order after an overnight fast. Blood samples were drawn before and 30, 60, 90, 120, 150 and 180 min after meal consumption (in total 266 samples) to determine glucose, insulin, ghrelin, peptide YY, glucagon-like peptide-1 and glicentin. Visual analog scales measuring the subjective perception of hunger and fullness were completed at the same time points. The test meal resulted in lower glucose incremental area under the curve (iAUC). Additionally, the iAUC of the ghrelin response over time was substantially lower after the test meal (p = 0.033). Lower desire to eat and higher fullness was reflected by significantly lower hunger iAUC (p = 0.046) and higher fullness iAUC (p = 0.042) after the test meal. No differences in insulin, PYY, GLP-1 and glicentin were observed. Pleurotus eryngii can ameliorate postprandial glycaemia, appetite and regulate ghrelin levels at the postprandial state. This effect is attributed to the bioactive polysaccharides that inhibit the activity of enzymes catalysing carbohydrate hydrolysis, cause a delayed gastric emptying and glucose absorption. Graphical Abstract: ga1