Saliva fatigue biomarker index as a marker for severe myalgic encephalomyelitis/chronic fatigue syndrome in a community based sample. Issue 4 (2nd October 2021)

• Record Type: Journal Article
• Authors: Jason, Leonard A.; Kalns, John; Richarte, Alicia; Katz, Ben Z.; Torres, Chelsea
• Is Part Of: Fatigue. Volume 9:Issue 4(2021)
• Page Start: 189
• Page End: 195
• Publication Date: 2021-10-02
• Subjects: Fatigue biomarker index -- chronc fatigue syndrome -- myalgic encephalomyelitis; Chronic fatigue syndrome -- Periodicals; Myalgic encephalomyelitis -- Periodicals; 616.047805
• DOI: 10.1080/21641846.2021.1994222
• Languages: English
• ISSNs: 2164-1846

Abstract

ABSTRACT : Objective: The prevalence of pediatric Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been estimated from an ethnically and sociodemographically diverse community-based random sample of 10, 119 youth aged 5–17. We assessed whether a salivary biomarker of fatigue could identify youth with ME/CFS. Study design: We examined the ratio of the concentrations of 2 peptide fragments in saliva, referred to as the Fatigue Biomarker Index (FBI), in participants from our study diagnosed with ME/CFS ( n = 59) and matched controls ( n = 39). Results: Significant overall differences were found in the FBI between those participants with severe ME/CFS and those with ME/CFS and the controls. Conclusions: If confirmed in other populations, the FBI could serve as an objective test to aid in the diagnosis of severe ME/CFS. Abbreviations : ANOVA: analysis of variance; BSA: bovine serum albumin; FBI: fatigue biomarker index; IM: infectious mononucleosis; ME/CFS: myalgic encephalomyelitis/chronic fatigue syndrome; OF: oral fluid; S-ME/CFS: severe myalgic encephalomyelitis/chronic fatigue syndrome