Combined ionic liquid and supercritical carbon dioxide based dynamic extraction of six cannabinoids from Cannabis sativa L. Issue 24 (26th November 2021)

• Record Type: Journal Article
• Authors: Kornpointner, Christoph; Sainz Martinez, Aitor; Schnürch, Michael; Halbwirth, Heidi; Bica-Schröder, Katharina
• Is Part Of: Green chemistry. Volume 23:Issue 24(2021)
• Page Start: 10079
• Page End: 10089
• Publication Date: 2021-11-26
• Subjects: Environmental chemistry -- Industrial applications -- Periodicals; Environmental management -- Periodicals; 660
• DOI: 10.1039/d1gc03516a
• Languages: English
• ISSNs: 1463-9262

Abstract

Abstract : A newly developed ionic liquid (IL) based supercritical CO2 extraction technique allows the solvent-free acquisition of cannabinoids from industrial hemp. Abstract : The potential of supercritical CO2 and ionic liquids (ILs) as alternatives to traditional extraction of natural compounds from plant material is of increasing importance. Both techniques offer several advantages over conventional extraction methods. These two alternatives have been separately employed on numerous ocassions, however, until now, they have never been combined for the extraction of secondary metabolites from natural sources, despite properties that complement each other perfectly. Herein, we present the first application of an IL-based dynamic supercritical CO2 extraction of six cannabinoids (CBD, CBDA, Δ 9 -THC, THCA, CBG and CBGA) from industrial hemp ( Cannabis sativa L.). Various process parameters were optimized, i.e., IL-based pre-treatment time and pre-treatment temperature, as well as pressure and temperature during supercritical fluid extraction. In addition, the impact of different ILs on cannabinoid extraction yield was evaluated, namely, 1-ethyl-3-methylimidazolium acetate, choline acetate and 1-ethyl-3-methylimidazolium dimethylphosphate. This novel technique exhibits a synergistic effect that allows the solvent-free acquisition of cannabinoids from industrial hemp, avoiding further processing steps and the additional use of resources. The newly developed IL-based supercritical CO2 extraction results in high yields of the investigated cannabinoids, thus, demonstrating an effective and reliable alternative to established extraction methods. Ultimately, the ILs can be recycled to reduce costs and to improve the sustainability of the developed extraction process.