Chemotherapeutic and Safety Profile of a Fraction from Mimosa caesalpiniifolia Stem Bark. (7th December 2021)

• Record Type: Journal Article
• Authors: Pinheiro Ferreira, Paulo Michel; Drumond, Renata Rosado; Silva, Jurandy do Nascimento; Oliveira Sousa, Ian Jhemes; Oliveira Barros de Alencar, Marcus Vinicius; Oliveira Ferreira da Mata, Ana Maria; Nery Monção, Nayana Bruna; Maria das Graças Lopes Citó, Antonia; Urano Carvalho, Ana Fontenele; Farias, Davi Felipe; Marçal da Costa, Patrícia; Viana Nunes, Adriana Maria; Marcelo de Castro e Sousa, João; Amélia de Carvalho Melo-Cavalcante, Ana
• Other Names: Qian Liren Academic Editor.
• Is Part Of: Journal of oncology. Volume 2021(2021)
• Publication Date: 2021-12-07
• Subjects: Oncology -- Research -- Periodicals; Tumors -- Periodicals; Neoplasms; Oncology -- Research; Tumors; Periodicals; Periodicals; 616.994
• DOI: 10.1155/2021/9031975
• Languages: English
• ISSNs: 1687-8450

Abstract

Abstract : Mimosa caesalpiniifolia (Fabaceae) is used by Brazilian people to treat hypertension, bronchitis, and skin infections. Herein, we evaluated the antiproliferative action of the dichloromethane fraction from M. caesalpiniifolia (DFMC) stem bark on murine tumor cells and the in vivo toxicogenetic profile. Initially, the cytotoxic activity of DFMC on primary cultures of Sarcoma 180 (S180) cells by Alamar Blue, trypan, and cytokinesis block micronucleus (CBMN) assays was assessed after 72 h of exposure, followed by the treatment of S180-bearing Swiss mice for 7 days, physiological investigations, and DNA/chromosomal damage. DFMC and betulinic acid revealed similar in vitro antiproliferative action on S180 cells and induced a reduction in viable cells, induced a reduction in viable cells and caused the emergence of bridges, buds, and morphological features of apoptosis and necrosis. S180-transplanted mice treated with DFMC (50 and 100 mg/kg/day), a betulinic acid-rich dichloromethane, showed for the first time in vivo tumor growth reduction (64.8 and 80.0%) and poorer peri- and intratumor quantities of vessels. Such antiproliferative action was associated with detectible side effects (loss of weight, reduction of spleen, lymphocytopenia, and neutrophilia and increasing of GOT and micronucleus in bone marrow), but preclinical general anticancer properties of the DFMC were not threatened by toxicological effects, and these biomedical discoveries validate the ethnopharmacological reputation of Mimosa species as emerging phytotherapy sources of lead molecules.