Novel Chitosan Polymer Design, Synthesis Using Mentha piperita of ZnO NPs as a Catalyst: Antibacterial Evaluation against Gram-Negative Multidrug-Resistant Pathogens. (9th December 2021)

• Record Type: Journal Article
• Authors: Packialakshmi, Ponnusamy; Gobinath, Perumal; Ali, Daoud; Alarifi, Saud; Ravindran, Balasubramani; Idhayadhulla, Akbar; Surendrakumar, Radhakrishnan
• Other Names: Yao Hui Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2021(2021)
• Publication Date: 2021-12-09
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2021/8804837
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : The goal of this research is to create a novel Schiff base of chitosan polymer derivatives 1a-1j. Nanotechnology is a promising field since it avoids the usage of hazardous chemicals while also saving time. Using the leaf extract of the pharmacologically valuable herb Mentha piperita, we described a green synthesis of ZnO NPs. Zinc oxide ions may be easily reduced into ZnO NPs using a Mentha piperita extract. ZnO NPs were employed as a phytocatalyst in this investigation to make chitosan derivatives. The synthetic procedure is straightforward, with a short reaction time and a high yield. Our newly synthesized compounds have been characterized by FTIR and nuclear magnetic resonance spectroscopy ( 1 H NMR and 13 C NMR), and morphology analysis was observed by XRD, SEM, and TEM. In addition, the antibacterial activity was also evaluated against gram-positive bacteria and gram-negative bacteria. Compound 1b is extremely active against gram-negative bacteria (4.0 μ g/mL, E. coli ), and compound 1h is highly active against gram-positive bacteria (6.0 μ g/mL, S. aureus ) compared with standard erythromycin and other chitosan derivatives. As a result, compounds 1b and 1h could be a high crucial molecule in the development of antibacterial drugs.