Altered Hippocampal Resting-state Functional Connectivity in Highly Superior Autobiographical Memory. (1st January 2022)

• Record Type: Journal Article
• Authors: Daviddi, Sarah; Pedale, Tiziana; Serra, Laura; Macrì, Simone; Campolongo, Patrizia; Santangelo, Valerio
• Is Part Of: Neuroscience. Volume 480(2022)
• Page Start: 1
• Page End: 8
• Publication Date: 2022-01-01
• Subjects: HSAM Highly Superior Autobiographical Memory -- rsFC resting-state functional connectivity -- AMs autobiographical memories -- AD Alzheimer Disease; autobiographical memory -- hippocampus -- fMRI -- resting-state functional connectivity; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2021.11.004
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: Highly Superior Autobiographical Memory (HSAM) is a rare form of enhanced memory. Here we assessed hippocampal resting-state functional connectivity (HrsFC) in HSAM. HSAM subjects showed disrupted HrsFC with regions involved with salience detection. Conversely, individuals with HSAM revealed enhanced HrsFC with sensory regions. Overall, these findings suggest that HSAM might be enabled by an altered HrsFC. Abstract: Individuals with Highly Superior Autobiographical Memory (HSAM) provide the opportunity to investigate the neurobiological substrates of enhanced memory performance. While previous studies started to assess the neural correlates of memory retrieval in HSAM, here we assessed for the first time the intrinsic connectivity of a core memory region, the hippocampus, with the whole brain, in 8 HSAM subjects (HSAMs) and 21 controls during resting-state functional neuroimaging. We found in HSAMs vs. controls disrupted hippocampal resting-state functional connectivity (rsFC) with high-level control regions belonging to the saliency network (the anterior cingulate cortex and the left and right insulae), and to the ventral fronto-parietal attentional network (the temporo-parietal junction and the inferior frontal gyrus), also involved with salience detection. Conversely, HSAMs showed enhanced hippocampal rsFC with sensory regions along the fusiform gyrus and the inferior temporal cortex. This altered pattern of hippocampal rsFC might be interpreted as a reduced capability of HSAMs to discriminate and select salient information, with a subsequent increase in the probability to encode and consolidate sensory information irrespective of their task-relevancy. Ultimately, these findings provide evidence that HSAM might be paradoxically enabled by an altered hippocampal rsFC that bypasses regions involved with salience detection in favor of specialized sensory regions.