Biocompatibility and Cu ions release kinetics of copper-bearing titanium alloys. (30th December 2021)

• Record Type: Journal Article
• Authors: Ren, Ling; Xu, Xiaohe; Liu, Hui; Yang, Ke; Qi, Xun
• Is Part Of: Journal of materials science & technology. Volume 95(2022)
• Page Start: 237
• Page End: 248
• Publication Date: 2021-12-30
• Subjects: Cu ions -- Kinetic -- Biocompatibility -- Titanium; Metals -- Periodicals; Materials science -- Periodicals; Materials science; Metals; Periodicals; 620.1105
• DOI: 10.1016/j.jmst.2021.03.074
• Languages: English
• ISSNs: 1005-0302

Abstract

Highlights: Biocompatibility of Cu-bearing titanium alloys meets requirements of ISO standards. Cu ions release kinetic from Ti-Cu alloy is in line with the zero-order model. Ti6Al4V-Cu and Ti-Cu have satisfactory biocompatibility both in vitro and in vivo . Abstract: To reduce the risk of implant-associated infections, we previously designed and developed a series of medical copper (Cu)-bearing titanium alloys that release Cu ions and hence play an antibacterial role. However, both excessive and deficient Cu levels adversely affect human health; therefore, the aim of the present study was to comprehensively evaluate the short- and long-term biosafety of Cu-bearing titanium alloys (Ti6Al4V-Cu and Ti-Cu) both in vitro and in vivo . Moreover, the predominant kinetic mechanism of Cu ions release and its effect on biosafety were also investigated. The results indicate that the biocompatibility of the Cu-bearing titanium alloys meets the requirements of ISO standards and the Cu ion release kinetics display a good correlation over the entire time period in the normal zero-order model with an almost constant release rate. The release rate maintained at a parts per billion level safe for humans; consequently, we can conclude that our Cu-bearing titanium alloys have satisfactory biocompatibility. Graphical abstract: Image, graphical abstract