Can lightning strike twice? Wild-type transthyretin cardiac amyloidosis associated with rare liver disease. Issue 11 (11th December 2021)

• Record Type: Journal Article
• Authors: Bhattacharya, Priyanka T; Fox, Alyson N; Marboe, Charles C; Lagana, Stephen M; Remotti, Helen E; D'Armiento, Jeanine M; Goldklang, Monica P; Eisenberger, Andrew B; Griffin, Jan M; Maurer, Mathew S
• Is Part Of: Oxford medical case reports. Volume 2021:Issue 11/12(2021)
• Publication Date: 2021-12-11
• Subjects: Clinical medicine -- Case studies -- Periodicals; 616.09
• DOI: 10.1093/omcr/omab113
• Languages: English
• ISSNs: 2053-8855

Abstract

ABSTRACT: Wild-type ATTR cardiac amyloidosis (ATTRwt-CA) is not as rare as previously thought to be. Patients with infiltrative cardiac amyloidosis often present with right-sided heart failure (HF) symptomatology. Clinically significant liver disease and cirrhosis has not been reported in ATTRwt-CA. We present two cases of ATTRwt-CA with right-sided HF and abnormal liver function tests initially thought to be secondary to congestive hepatopathy but found to have rare and unrelated liver disease. These cases highlight the importance of developing a broad differential diagnosis and leveraging a multidisciplinary team approach in evaluating patients for unusual causes of cirrhosis/other chronic liver diseases when ATTR cardiac amyloidosis patients present with congestive hepatopathy.