Two new sesquiterpene aryl esters from Armillaria gallica 012m. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Lou, Shui-Zhu; Feng, Jian; Yang, Run; Li, Yan-Ping; Gao, Lu; Du, Gang; Yang, Hai-Ying; Hu, Qiu-Fen; Zhou, Wen-Bing; Wang, Li-Sheng; Wang, Wei-Guang
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 1(2022)
• Page Start: 59
• Page End: 65
• Publication Date: 2022-01-02
• Subjects: Tricholomataceae -- Armillaria gallica 012m -- sesquiterpene aryl ester -- cytotoxic activity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1878156
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Two new sesquiterpene aryl esters, armimelleolides A and B (1 and 2 ), and four known ones, were isolated from the EtOAc extract of Armillaria gallica 012 m by column chromatography on silica gel, reversed-phase C18 silica gel and semi-preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods, including extensive 1 D NMR, 2 D NMR and MS. All these compounds showed potential antitumor activities against at least one of the human cancer cell lines (A549, HCT-116, M231 and W256), with IC50 ranging from 2.57 to 19.94 μM. Graphical abstract: UF0001