Increasing Incidence of Cirrhosis Over the Past 2 Decades Among Children in Ontario, Canada. (18th January 2022)

• Record Type: Journal Article
• Authors: Kehar, Mohit; Griffiths, Rebecca; Flemming, Jennifer A.
• Is Part Of: American journal of gastroenterology. Volume 117:Number 1(2022)
• Page Start: 189
• Page End: 192
• Publication Date: 2022-01-18
• Subjects: Stomach -- Diseases -- Periodicals; Intestines -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Gastrointestinal Diseases -- Periodicals; Electronic journals; Periodicals; 616.33
• DOI: 10.14309/ajg.0000000000001564
• Languages: English
• ISSNs: 0002-9270

Abstract

Abstract : INTRODUCTION: We describe the incidence of cirrhosis in the general pediatric population. METHODS: This is a population-based study using health-care data from Ontario, Canada, between 1997 and 2017. Age-adjusted and sex-adjusted standardized incidence rates were described, and age-period-cohort modeling approach was used to estimate the independent effect of birth cohort. RESULTS: In total, 2, 966 new diagnoses of cirrhosis among children were identified at a median age of 9 years. The incidence rate increased almost 4-fold over the study period (2.7/100, 000 person-years in 1997 vs 10.6/100, 000 person-years in 2017) with the highest increase seen in children younger than 1 year. DISCUSSION: In this first population-based study in children, the incidence of cirrhosis has increased dramatically over the past 2 decades. Abstract :