Apolipoprotein A1 and Ceruloplasmin, the key crosstalk players between the liver and adipose tissue during early postpartum of buffaloes: An in-Silico transcriptome based network analysis. (November 2020)

• Record Type: Journal Article
• Authors: Sharma, Yuvraj; Verma, Surya Kant; Kumar, Lal Krishan; Surla, Gangu Naidu; Vedamurthy, Gowdar V.; Singh, Dheer; Onteru, Suneel Kumar
• Is Part Of: Computers in biology and medicine. Volume 126(2020)
• Publication Date: 2020-11
• Subjects: Post-partum -- Liver -- Adipose tissue -- Cross-talk -- Bioinformatics analyses -- PANTHER -- Endocrine/autocrine molecules; APOA1 apolipoprotein -- LTF lactoferrin -- ITPR3 inositol 1, 4, 5-triphosphate receptor -- CP ceruloplasmin -- AT adipose tissue -- LT Liver tissue -- NEB negative energy balance -- DEGs differentially expressed genes -- CC cellular component -- ECM extra cellular matrix -- ECR extra cellular region -- PPI protein-protein interaction -- PANTHER Protein ANalysis THrough Evolutionary -- STRING Search Tool for the Retrieval of Interacting -- CPDB Consensus Path DataBase -- NGS next generation sequencing -- VLDL very low density lipoproteins -- NEFAs non esterified fatty acids -- HDL high density lipoproteins; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2020.104024
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: Physiological transition from pregnancy to lactation during early postpartum creates a high-energy demand in females towards milk production for the survival of new offspring. Ruminant milk contains high amount of lactose, a disaccharide of the glucose and galactose. The milk yield of the animals is also dependent on the lactose amount. In ruminants, glucose is majorly supplied by the liver, which obtains energy from the adipose tissue during energy demands. Therefore, there should be an intricate crosstalk between these two tissues for efficient maintenance of energy for normal physiological needs and milk production. In the present study, we analyzed the transcriptome data previously obtained from the buffalo liver and adipose tissue on the 15th day and 30th day of lactation by using several bioinformatics tools such as PANTHER, Secretome-P, STRING and CPDB. Our analysis identified a total of 24 signaling molecules as interactive players between the liver and adipose tissue during early postpartum of buffaloes. Particularly, the liver appears to interact with the adipose tissue and itself majorly through an endocrine/autocrine molecule, APOA1. Similarly, the adipose tissue appears to interact with the liver and itself majorly through an endocrine/autocrine molecule, CP (ceruloplasmin). The APOA1 and CP may counteract with each other on lipolysis in buffalo adipose tissue because of their common signaling molecules being shared. In addition, the interaction between the adipose derived ceruloplasmin and the liver derived lactoferrin seems to be important during early postpartum of buffaloes. The importance of this interaction needs to be studied in further studies. Highlights: The liver and adipose tissue may crosstalk through 24 interactive players in buffalo during early postpartum. The liver majorly interacts with adipose tissue through an endocrine/autocrine molecule, APOA1, during early postpartum. The adipose tissue majorly interacts with the liver through an endocrine/autocrine molecule, CP, during early postpartum. The APOA1 and CP may counteract on lipolysis in adipose tissue because of the common signaling molecules being shared. The interaction between an adipokine, CP and the LTF from the liver seems to be important during early postpartum..