Injectable hydrogel for postoperative synergistic photothermal-chemodynamic tumor and anti-infection therapy. (January 2022)

• Record Type: Journal Article
• Authors: Huang, Han; Wang, Xiaorui; Wang, Weili; Qu, Xinyu; Song, Xuejiao; Zhang, Yewei; Zhong, Liping; Yang, Da-peng; Dong, Xiaochen; Zhao, Yongxiang
• Is Part Of: Biomaterials. Volume 280(2022)
• Publication Date: 2022-01
• Subjects: Bioactive glass nanoparticles -- Tumor inhibition -- Antibacterial -- Wound healing -- Photothermal-chemodynamic therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2021.121289
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Tumor surgery is usually accompanied by neoplasm residual, tissue defects, and multi-drug resistant bacterial infection, causing high tumor recurrence, low survival rate, and chronic wounds. Herein, a light-activated injectable hydrogel based on bioactive nanocomposite system is developed by incorporating Ag2 S nanodots conjugated Fe-doped bioactive glass nanoparticles (BGN-Fe-Ag2 S) into biodegradable PEGDA and AIPH solution for inhibiting tumor growth, treating bacterial infection, and promoting wound healing. Under laser irradiation, the photothermal effect mediated by Ag2 S nanodots would trigger the decomposition of AIPH, generating alkyl radicals to initiate the gelation of PEGDA. The in-situ gelatinized hydrogel, with outstanding photothermal effect and chemodynamic effect derived from the doped Fe in BGN-Fe-Ag2 S, can not only eliminate multidrug-resistant bacteria but also efficiently ablated tumor during treatment. Moreover, the hydrogel significantly accelerated wound healing with more skin appendages in the full-thickness cutaneous wounds model because of the hydrolysis of bioactive glass. These results manifest that this multifunctional hydrogel is a suitable biomaterial to inhibit tumor proliferation and overcome tissue bacterial infection after surgical removal of tumors.