One uncommon bis-sesquiterpenoid from Xisha soft coral Litophyton nigrum. (5th January 2022)

• Record Type: Journal Article
• Authors: Yang, Fan; Hua, Qiang; Yao, Li-Gong; Liang, Lin-Fu; Lou, Yu-Xia; Lu, Yan-Hua; An, Fa-Liang; Guo, Yue-Wei
• Is Part Of: Tetrahedron letters. Volume 88(2022)
• Publication Date: 2022-01-05
• Subjects: Litophyton nigrum -- Soft coral -- Bis-sesquiterpenoid -- Nardosinane; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2021.153571
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Abstract: One uncommon sesquiterpenoid dimer (1 ), a new nardosinane-type sesquiterpenoid (3 ), along with two known sesquiterpenoids (2 and 4 ) were isolated from soft coral Litophyton nigrum using a structure-oriented HR-MS/MS approach. The configurations of the isolates were determined by spectroscopic data analyses, including HR-ESI-MS, 1D/2D NMR, single crystal X-ray diffraction, and DP4+ statistical analyses. Compound 3 exhibited potent PTP1B inhibitory activity (IC50 = 10.67 ± 1.81 μg/mL) compared to the positive control.